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Who the heck are YOU?
Not all Li-Ion batteries will drop from 4.2V to 3.8V in under a minute. If you are using 2 18650's, you will have significantly longer regulated runtime than if you were using 2 10440's. With a boost driver, you get regulation for the whole time, but since you are boosting the voltage, you are pulling more current from the cell at 3.6V than you are sending to the LD at 5V. At some point, overdischarging the Li-Ion cell may become an issue.
"Check out my BR lazor, it burnz at 900mW!"
*Cue single 10440 cell venting with flame*
So, under certain circumstances, I could see using only 2 Li-Ions as feasible. But having control over the entire build, you shouldn't have to make that sort of concession.