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Using a 405nm laser to treat acne?

WizardG

WizardG

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I hadn't done any specific research on the subject but I knew that most microorganisms are vulnerable to ultraviolet light. I just tried it based on that general principal and hoped the 405 would be high enough energy, and bright enough, to do the job. The fungus had been getting slowly worse (bigger uglier section of the nail every month) over the course of about a year. I used the laser over 2 years ago and I haven't seen any recurrance yet.
 





A

arcaneinsomniac

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Incredible. You killed 'em all dead.

I think its better to stay as close to the visible range as possible because it is much safer because you can see it, and also higher energy UV has carcinogenic potential. But 405 isn't really UV, only under 400nm is technically UV.

My acne isn't completely fixed. I might go and pick up an uncollimated UV LED light so I can do some more treatment.
 
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WizardG

WizardG

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Yeah, I don't know if i would have tried it with a 365nM laser. A 365 might be fun to 'write' things on people tanning at the beach though. Portable galvo scanner to 'draw' things on someone's skin for ~ 15 minutes then wait overnight for the image to develop! LOL
 
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Cyparagon

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WizardG said:
fgsfds.jpg
Click to expand...

Because the scientific method is over-rated. Anecdotal evidence 4 teh win. :tired:

Also, post hoc.
 
WizardG

WizardG

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LOL, gimmee a break Cy', I'm an engineer not a biologist! But yeah, this is not what you'd call a controlled experiment by any stretch of the imagination. And who knows, maybe I'll die of toe cancer when I'm 70.
 
A

ankh

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Here's one on fungus, good news (if you're a tomato, or tomato farmer).
Dunno how it would relate to toenail fungus, but ...??

Lett Appl Microbiol. 2014 Dec;59(6):670-6. doi: 10.1111/lam.12330. Epub 2014 Oct 20.
Antifungal effect of 405-nm light on Botrytis cinerea.

Antifungal effect of 405-nm light on Botrytis cinerea. - PubMed - NCBI

There is very little information on the fungistatic or fungicidal effect of visible light. This study investigated the effect of 405-nm light, generated by a light-emitting diode array, on the economically important fungus Botrytis cinerea. The mycelial growth of B. cinerea was inhibited to the greatest extent by light at 405 and 415 nm and was negligibly inactivated at 450 nm, suggesting the presence of a photosensitizing compound that absorbs light mainly at wavelengths of 405-415 nm. Delta-aminolevulinic acid, a precursor of endogenous photosensitizer porphyrins, was used to determine the role of these porphyrins in 405-nm light-mediated photoinactivation of the fungus. Concentration-dependent inhibition of spore germination by delta-aminolevulinic acid and accumulation of singlet oxygen in the spores was observed when the spores were exposed to 405-nm light. These results suggest that the excitation of endogenous porphyrins and subsequent accumulation of singlet oxygen could partially explain the 405-nm light-mediated photoinactivation of B. cinerea. The development of symptoms in detached tomato leaves inoculated with B. cinerea spores was significantly reduced by irradiation with 405-nm light, indicating that 405-nm light has a potential use for controlling plant diseases caused by B. cinerea.
SIGNIFICANCE AND IMPACT OF THE STUDY:

Grey mould (Botrytis cinerea) is a very successful necrotroph, causing serious losses in more than 200 crop hosts. This study investigated the antifungal effect of 405-nm light on this pathogen. Our results suggest that the excitation of endogenous porphyrins and subsequent accumulation of singlet oxygen contribute to the 405-nm light-mediated photoinactivation of grey mould. The development of symptoms in detached tomato leaves inoculated with B. cinerea spores was significantly inhibited by irradiation with 405-nm light, indicating that this wavelength of light has a potential use in controlling plant diseases caused by B. cinerea.
 
olympus mons

olympus mons

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ankh said:
Here's one on fungus, good news (if you're a tomato, or tomato farmer).
Dunno how it would relate to toenail fungus, but ...??

Lett Appl Microbiol. 2014 Dec;59(6):670-6. doi: 10.1111/lam.12330. Epub 2014 Oct 20.
Antifungal effect of 405-nm light on Botrytis cinerea.

Antifungal effect of 405-nm light on Botrytis cinerea. - PubMed - NCBI

There is very little information on the fungistatic or fungicidal effect of visible light. This study investigated the effect of 405-nm light, generated by a light-emitting diode array, on the economically important fungus Botrytis cinerea. The mycelial growth of B. cinerea was inhibited to the greatest extent by light at 405 and 415 nm and was negligibly inactivated at 450 nm, suggesting the presence of a photosensitizing compound that absorbs light mainly at wavelengths of 405-415 nm. Delta-aminolevulinic acid, a precursor of endogenous photosensitizer porphyrins, was used to determine the role of these porphyrins in 405-nm light-mediated photoinactivation of the fungus. Concentration-dependent inhibition of spore germination by delta-aminolevulinic acid and accumulation of singlet oxygen in the spores was observed when the spores were exposed to 405-nm light. These results suggest that the excitation of endogenous porphyrins and subsequent accumulation of singlet oxygen could partially explain the 405-nm light-mediated photoinactivation of B. cinerea. The development of symptoms in detached tomato leaves inoculated with B. cinerea spores was significantly reduced by irradiation with 405-nm light, indicating that 405-nm light has a potential use for controlling plant diseases caused by B. cinerea.
SIGNIFICANCE AND IMPACT OF THE STUDY:

Grey mould (Botrytis cinerea) is a very successful necrotroph, causing serious losses in more than 200 crop hosts. This study investigated the antifungal effect of 405-nm light on this pathogen. Our results suggest that the excitation of endogenous porphyrins and subsequent accumulation of singlet oxygen contribute to the 405-nm light-mediated photoinactivation of grey mould. The development of symptoms in detached tomato leaves inoculated with B. cinerea spores was significantly inhibited by irradiation with 405-nm light, indicating that this wavelength of light has a potential use in controlling plant diseases caused by B. cinerea.
Click to expand...

Thanks for posting this info. Just to give you a heads up for some reason it is frowned upon to post on old threads here at LPF. I don't really agree with the policy nor understand exactly why its so "bad" but some will neg rep peole for it.
You could always make a thread on this topic considering the information you shared.
Thanks and welcome to LPF!!!!
 
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clansley

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Isn't the rule that it's ok to post to a old thread if you have new information. I think somebody has that rule in their Sig.
 
InfinitusEquitas

InfinitusEquitas

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There is really no written hard rule, it's more a strong implication to please not post in an old thread unless adding new information to it.

For the most part no one cares, but some people do get bent out of shape when there is a 2-3 year old thread and it gets bumped because someone posts "Cool pictures!" or "That's interesting."

It's a plus and a minus that threads here are usually left open indefinitely.
 
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